Evaluation of Renal Clinicopathological Changes in IgA Nephropathy by Urinary Podocytes Excretion and Podocalyxin Expression
نویسندگان
چکیده
منابع مشابه
Urinary Periostin Excretion Predicts Renal Outcome in IgA Nephropathy.
BACKGROUND Periostin is a matricellular protein and plays a vital role in tissue regeneration, fibrosis and wound healing. However, data about its significance in nephrology are limited. We investigated the correlation between urinary periostin excretion and its clinical significance including renal histologic findings and prognosis in IgA nephropathy (IgAN). METHODS Of 399 patients from a gl...
متن کاملRelationships between levels of urinary podocalyxin, number of urinary podocytes, and histologic injury in adult patients with IgA nephropathy.
BACKGROUND AND OBJECTIVES Podocalyxin (PCX) is present on the apical cell membrane of podocytes and is shed in urine from injured podocytes. Urinary podocalyxin (u-PCX) is associated with severity of active glomerular injury in patients with glomerular diseases. This study examined the relationship between number of urinary podocytes, levels of u-PCX, and glomerular injury in adults with IgA ne...
متن کاملUrinary excretion of viable podocytes in health and renal disease.
The loss of glomerular visceral epithelial cells (podocytes) has been associated with the development of glomerular sclerosis and loss of renal function. Viability of podocytes recovered from urine of subjects with glomerular disease and of healthy controls was investigated by propidium iodide exclusion and TUNEL staining. Podocyte loss was quantified by cytospin. The growth behavior in culture...
متن کاملUrinary Excretion of Interleukin-6 in Pediatric IgA Nephropathy Patients
Objective: Urinary excretion of interleukin-6 (U-IL6) has been reported to be elevated and to represent the disease activity in adult IgA nephropathy (IgAN). We investigated the significance and the utility of U-IL6 activity in pediatric IgAN patients. Methods: We evaluated 55 pediatric IgAN patients (4–18 years; mean age, 10.7 years) and 53 healthy controls from 2007 to 2012. The U-IL6 concent...
متن کاملAltered urinary excretion of aquaporin 2 in IgA nephropathy.
OBJECTIVE The intrarenal renin-angiotensin system (RAS) activation plays a pivotal role in immunoglobulin A nephropathy (IgAN) pathogenesis, which is still largely undefined. Recently, vasopressin (AVP) has been advocated to contribute to the genesis and progression of chronic kidney diseases (CKD) directly, and indirectly, via RAS activation. Our aim is to explore the intrarenal activity of AV...
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ژورنال
عنوان ژورنال: Renal Failure
سال: 2012
ISSN: 0886-022X,1525-6049
DOI: 10.3109/0886022x.2011.643352